https://doi.org/10.1172/jci.understanding.95874.. adult Wnt proteins, or genetically reducing the manifestation of (which encodes -catenin), suppressed the forming of renal cysts, improved renal function, and prolonged success in ADPKD mice. Our research obviously demonstrates the need for -catenin signaling in disease phenotypes connected with mutation. It describes the consequences of two Wnt inhibitors also, LGK974 and XAV939, … Continue reading https://doi